PD 198306

Tocris Bioscience | Catalog # 2605

Selective inhibitor of MEK1/2
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of MEK1/2
View all MEK Inhibitors »

Product Description

PD 198306 is a potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Highly selective for MEK; IC50 values are > 1, > 4, > 4 and > 10 μM for ERK, c-Src, cdks and PI 3-kinase γ respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration.

Product Specifications for PD 198306

Molecular Weight

476.23

Formula

C18H16F3IN2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide

CAS Number

212631-61-3

PubChem ID

9956637

InChI Key

UHAXDAKQGVISBZ-UHFFFAOYSA-N

SMILES

CC1=C(NC2=C(C=C(F)C(F)=C2F)C(=O)NOCC2CC2)C=CC(I)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.62 100
Ethanol 47.62 100

Preparing Stock Solutions for PD 198306

The following data is based on the product molecular weight 476.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.10 mL 10.50 mL 21.00 mL
5 mM 0.42 mL 2.10 mL 4.20 mL
10 mM 0.21 mL 1.05 mL 2.10 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for PD 198306

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 198306

For research use only

Customer Reviews for PD 198306 (1)

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  • In vitro culture
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: SH-SY5Y
    Verified Customer | Posted 08/05/2018
    Used in vitro as ERK inhibitor in SH-SY5Y at 10 uM. Good performance.
    PD 198306 2605

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