PDEδ ATTEC 12C

Key Product Details

Product Description

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC₅₀ = 1.7 μM; D_max = 85%; K_d = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC₅₀ values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.

Product Specifications for PDEδ ATTEC 12C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PDEδ ATTEC 12C

The following data is based on the product molecular weight 999.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	5.00 mL	25.01 mL	50.02 mL
1 mM	1.00 mL	5.00 mL	10.00 mL
2 mM	0.50 mL	2.50 mL	5.00 mL
10 mM	0.10 mL	0.50 mL	1.00 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bao Discovery of novel PDEδ autophagic degraders: a case study of autophagy-tethering compound (ATTEC). ACS Med.Chem.Lett. 2024 PMID: 38229750

Product Documents for PDEδ ATTEC 12C