Novel cyclic peptide that disrupts interaction between GluR6 and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluR6 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.
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Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide.
Piserchio et al.