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PDZ1 Domain inhibitor peptide

2207 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2207/1
PDZ1 Domain inhibitor peptide
1 Image
Description: Disrupts interaction between GluK2 and PSD-95 PDZ1 domain
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Biological Activity

Novel cyclic peptide that disrupts interaction between GluK2 (formerlyy GluR6) and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluK2 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
819.95
Formula:
C38H61N9O11
Sequence:
YKKTEAV

(Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6))

Solubility:
Soluble to 1 mg/ml in 5% acetonitrile / water and to 4 mg/ml in DMSO
Storage:
Desiccate at -20°C
CAS No:
1315378-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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