PDZ1 Domain inhibitor peptide
Biological ActivityPDZ1 Domain inhibitor peptide is a novel cyclic peptide that disrupts interaction between GluK2 (formerlyy GluR6) and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluK2 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
(Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6))
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide.
Piserchio et al.
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