PE 22-28

Name: PE 22-28
Brand: Tocris Bioscience
SKU: 7868
Price: 201 USD
Availability: InStock

Tocris Bioscience | Catalog # 7868

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Citations (1)

Product Documents

Potent inhibitor of TREK-1 channels

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent inhibitor of TREK-1 channels

View all Two-P Potassium Channel Inhibitors »

Product Description

PE 22-28 is a potent inhibitor of potassium channel subfamily K member 2/TREK-1 (IC₅₀ = 0.12 nM). In rodent models of ischemia PE 22-28 reduces apoptotic death of β cells, increases hippocampal neurogenesis, and reduces stroke-induced motor and cognitive defects.

Product Specifications for PE 22-28

Molecular Weight

773.89

Formula

C₃₅H₅₅N₁₁O₉

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1801959-12-5

PubChem ID

165437303

InChI Key

CMNBQRXBBJQIOA-YIHYGEMESA-N

SMILES

O=C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Mass

Concentration

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Background References

References are publications that support the biological activity of the product.

Pietri First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides. Neuropharmacology 2019 PMID: 31325429
Daziano Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway. Pharmacol.Res. 2021 PMID: 33737242

Product Documents for PE 22-28

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for PE 22-28

For research use only

Citations for PE 22-28

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