Catalog Number: 5018
Chemical Name: [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
Biological Activity
Potent NMDA receptor antagonist (IC50 = 8 nM). Exhibits >100-fold selectivity for hNR2A containing receptors over hNR2B. Anticonvulsant in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water with gentle warming
  • Purity:
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.
    Auberson et al.
    Bioorg.Med.Chem.Lett., 2002;12:1099
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