Potent NMDA receptor antagonist (IC50
= 8 nM). Exhibits >100-fold selectivity for hNR2A containing receptors over hNR2B. Anticonvulsant in vivo
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5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.
Auberson et al.