Chemical Name: 4,4'-(Pentamethylenedioxy)dibenzamidine bis-2-hydroxyethanesulfonate salt
Biological ActivityPentamidine isethionate is an antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.
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Pentamidine is an N-MthD.-aspartate receptor antagonist and is neuroprotective in vitro.
Reynolds and Aizeman
Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist.
Kitamura et al.
Citation for Pentamidine isethionate
The citations listed below are publications that use Tocris products. Selected citations for Pentamidine isethionate include:
1 Citation: Showing 1 - 1
S100B-p53 disengagement by pentam. promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells.
Authors: Capoccia Et al.
Oncol Lett 2015;9:2864
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