Catalog Number: 3277
Chemical Name: 4,4'-(Pentamethylenedioxy)dibenzamidine bis-2-hydroxyethanesulfonate salt
Biological Activity
Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.
Technical Data
  • M.Wt:
    592.68
  • Formula:
    C19H24N4O2.2C2H6O4S
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    140-64-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro.
    Reynolds and Aizeman
    J.Neurosci., 1992;12:970
  2. Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist.
    Kitamura et al.
    Eur.J.Pharmacol., 1995;289:299
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pentamidine isethionate include:

1 Citations: Showing 1 - 1

  1. S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells.
    Authors: Capoccia Et al.
    Oncol Lett 2015;9:2864

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