Catalog Number: 2033
Alternate Names: Deoxycoformycin
Chemical Name: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Biological Activity
Irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.
Technical Data
  • M.Wt:
    268.27
  • Formula:
    C11H16N4O4
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    53910-25-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pentostatin: future directions.
    Klohs and Kraker
    Pharmacol.Rev., 1992;44:459
  2. Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era.
    Nabhan et al.
    Leukemia Res., 2004;28:429
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pentostatin include:

3 Citations: Showing 1 - 3
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  1. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
    Authors: Song
    Nat Commun 2017;8:14108
  2. Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
    Authors: Ledderose Et al.
    Purinergic Signalling 2016;
  3. Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances.
    Authors: Li Et al.
    PLoS Comput Biol 2015;3:e00121

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