Pentostatin

Tocris Bioscience | Catalog # 2033

Adenosine deaminase inhibitor
Tocris Bioscience

Key Product Details

Description

Adenosine deaminase inhibitor

Alternative Names

Deoxycoformycin
View all Deaminase Inhibitors »

Product Description

Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.

Product Specifications for Pentostatin

Molecular Weight

268.27

Formula

C11H16N4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

CAS Number

53910-25-1

PubChem ID

439693

InChI Key

FPVKHBSQESCIEP-JQCXWYLXSA-N

SMILES

O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CNC[C@H]3O)=C3N=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.83 100
DMSO 20.12 75

Preparing Stock Solutions for Pentostatin

The following data is based on the product molecular weight 268.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.73 mL 18.64 mL 37.28 mL
5 mM 0.75 mL 3.73 mL 7.46 mL
10 mM 0.37 mL 1.86 mL 3.73 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

  • Nabhan Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res.
  • Klohs and Kraker Pentostatin: future directions. Pharmacol.Rev. 1992 PMID: 1480666

Product Documents for Pentostatin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pentostatin

For research use only

⚠ WARNING: This product can expose you to chemicals including Pentostatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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