Chemical Name: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Biological ActivityPentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pentostatin: future directions.
Klohs and Kraker
Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era.
Nabhan et al.
Leukemia Res., 2004;28:429
Citations for Pentostatin
The citations listed below are publications that use Tocris products. Selected citations for Pentostatin include:
3 Citations: Showing 1 - 3
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
Nat Commun 2017;8:14108
Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
Authors: Ledderose Et al.
Purinergic Signalling 2016;
Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances.
Authors: Li Et al.
PLoS Comput Biol 2015;3:e00121
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