Catalog # Availability Size / Price Qty
Pentylenetetrazole | CAS No. 54-95-5 | Additional GABA Compounds
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Description: CNS stimulant
Alternative Names: PTZ

Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine

Purity: ≥99%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems.
    Rocha et al.
    Epilepsy Res., 1996;26:105
  2. Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density.
    Walsh et al.
    J.Pharmacol.Exp.Ther., 1999;289:1626
  3. Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action.
    Dhir et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 2006;30:1478

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Citation for Pentylenetetrazole

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Use of pentylenetetrazole as GABA-A receptor antagonist
By Anonymous on 08/31/2019
Application: Species: Mouse

Pentylenetetrazole was used for pharmacological isolation of glycine receptors response as a GABA-A receptor antagonist with low or no affinity to glycine receptor (GlyR). Clear GlyR single-channel openings with characteristic conductance states were obtained. Figure: recording of GlyR single-channel openings with 1 mM pentylenetetrazole in perfusion solution.

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