Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
Biological ActivityPentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems.
Rocha et al.
Epilepsy Res., 1996;26:105
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density.
Walsh et al.
Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action.
Dhir et al.
Citation for Pentylenetetrazole
The citations listed below are publications that use Tocris products. Selected citations for Pentylenetetrazole include:
1 Citation: Showing 1 - 1
2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.
Authors: Karim Et al.
Br J Pharmacol 2012;165:880
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Pentylenetetrazole
Average Rating: 5 (Based on 1 Review)
Have you used Pentylenetetrazole?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Pentylenetetrazole was used for pharmacological isolation of glycine receptors response as a GABA-A receptor antagonist with low or no affinity to glycine receptor (GlyR). Clear GlyR single-channel openings with characteristic conductance states were obtained. Figure: recording of GlyR single-channel openings with 1 mM pentylenetetrazole in perfusion solution.