Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
Biological ActivityCNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems.
Rocha et al.
Epilepsy Res., 1996;26:105
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density.
Walsh et al.
Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action.
Dhir et al.
Citation for Pentylenetetrazole
The citations listed below are publications that use Tocris products. Selected citations for Pentylenetetrazole include:
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2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.
Authors: Karim Et al.
Br J Pharmacol 2012;165:880
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Pentylenetetrazole was used for pharmacological isolation of glycine receptors response as a GABA-A receptor antagonist with low or no affinity to glycine receptor (GlyR). Clear GlyR single-channel openings with characteristic conductance states were obtained. Figure: recording of GlyR single-channel openings with 1 mM pentylenetetrazole in perfusion solution.