Pentylenetetrazole

Tocris Bioscience | Catalog # 2687

CNS stimulant
Tocris Bioscience

Key Product Details

Description

CNS stimulant

Alternative Names

PTZ
View all Additional GABA Compounds »

Product Description

Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

Product Specifications for Pentylenetetrazole

Molecular Weight

138.17

Formula

C6H10N4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine

CAS Number

54-95-5

PubChem ID

5917

InChI Key

CWRVKFFCRWGWCS-UHFFFAOYSA-N

SMILES

C1CCN2N=NN=C2CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.81 100
DMSO 13.81 100

Preparing Stock Solutions for Pentylenetetrazole

The following data is based on the product molecular weight 138.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.24 mL 36.19 mL 72.37 mL
5 mM 1.45 mL 7.24 mL 14.47 mL
10 mM 0.72 mL 3.62 mL 7.24 mL
50 mM 0.14 mL 0.72 mL 1.45 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for Pentylenetetrazole

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pentylenetetrazole

For research use only

Related Research Areas

Osteoblast and Osteoclast Markers

Citations for Pentylenetetrazole

Customer Reviews for Pentylenetetrazole (1)

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  • Use of pentylenetetrazole as GABA-A receptor antagonist
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Cerebellum
    Verified Customer | Posted 08/31/2019
    Pentylenetetrazole was used for pharmacological isolation of glycine receptors response as a GABA-A receptor antagonist with low or no affinity to glycine receptor (GlyR). Clear GlyR single-channel openings with characteristic conductance states were obtained. Figure: recording of GlyR single-channel openings with 1 mM pentylenetetrazole in perfusion solution.
    Pentylenetetrazole 2687

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