Catalog Number: 2687
Alternate Names: PTZ
Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
Biological Activity
CNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems.
    Rocha et al.
    Epilepsy Res., 1996;26:105
  2. Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density.
    Walsh et al.
    J.Pharmacol.Exp.Ther., 1999;289:1626
  3. Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action.
    Dhir et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 2006;30:1478
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