Biological ActivityPep 2-8 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
(Modifications: Thr-1 = N-terminal Ac, Val-13 = C-terminal amide)
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Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.
Zhang et al.
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