Catalog Number: 1599
Biological Activity
Inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluR2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluR2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 1 mg/ml in PBS (pH6.8)
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
    Li et al.
    Nat.Neurosci., 1999;2:972
  2. Functional roles of protein interactions with AMPA and kainate receptors.
    Collingridge and Isaac
    Neurosci.Res., 2003;47:3
  3. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
    Daw et al.
    Neuron, 2000;28:873
  4. Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
    Hanley et al.
    Neuron, 2002;34:53

The citations listed below are publications that use Tocris products. Selected citations for pep2-EVKI include:

Showing Results 1 - 2 of 2

  1. A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha.
    Authors: Dickinson Et al.
    Mol Brain
  2. PKM ζ maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors.
    Authors: Yao Et al.
    Proc Natl Acad Sci U S A
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information