Catalog Number: 1599
Biological Activity
Inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluR2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluR2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
Technical Data
  • M.Wt:
    1326.51
  • Formula:
    C62H95N13O19
  • Sequence:
    YNVYGIEEVKI
  • Solubility:
    Soluble to 1 mg/ml in PBS (pH6.8)
  • Storage:
    Desiccate at -20°C
  • CAS No:
    1315378-67-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
    Li et al.
    Nat.Neurosci., 1999;2:972
  2. Functional roles of protein interactions with AMPA and kainate receptors.
    Collingridge and Isaac
    Neurosci.Res., 2003;47:3
  3. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
    Daw et al.
    Neuron, 2000;28:873
  4. Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
    Hanley et al.
    Neuron, 2002;34:53
Citations:

The citations listed below are publications that use Tocris products. Selected citations for pep2-EVKI include:

2 Citations: Showing 1 - 2
Filter your results:

  1. A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha.
    Authors: Dickinson Et al.
    Mol Brain 2009;2:18
  2. PKM ζ maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors.
    Authors: Yao Et al.
    Proc Natl Acad Sci U S A 2008;28:7820

Have you used pep2-EVKI?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information