Biological ActivityInhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Functional roles of protein interactions with AMPA and kainate receptors.
Collingridge and Isaac
PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
Daw et al.
Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
Hanley et al.
AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
Li et al.
Citations for pep2-EVKI
The citations listed below are publications that use Tocris products. Selected citations for pep2-EVKI include:
2 Citations: Showing 1 - 2
A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha.
Authors: Dickinson Et al.
Mol Brain 2009;2:18
PKM ζ maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors.
Authors: Yao Et al.
Proc Natl Acad Sci U S A 2008;28:7820
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