Biological Activitypep2-EVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Functional roles of protein interactions with AMPA and kainate receptors.
Collingridge and Isaac
PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
Daw et al.
Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
Hanley et al.
AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
Li et al.
Citations for pep2-EVKI
The citations listed below are publications that use Tocris products. Selected citations for pep2-EVKI include:
2 Citations: Showing 1 - 2
A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha.
Authors: Dickinson Et al.
Mol Brain 2009;2:18
PKM ζ maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors.
Authors: Yao Et al.
Proc Natl Acad Sci U S A 2008;28:7820
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