Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor. Inhibits palmitate oxidation in rat cardiomyocytes and increases cardiac efficiency in isolated rat hearts. Antianginal.
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Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone.
Kennedy et al.
Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium.
Unger et al.
Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.
Yin et al.