Catalog Number: 5166
Chemical Name: 2-(2,2-Dicyclohexylethyl)piperidine maleate
Biological Activity
Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor. Inhibits palmitate oxidation in rat cardiomyocytes and increases cardiac efficiency in isolated rat hearts. Antianginal.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone.
    Kennedy et al.
    Biochem.Pharmacol., 1996;52:273
  2. Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium.
    Unger et al.
    J.Cardiovasc.Pharmacol., 2005;46:849
  3. Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.
    Yin et al.
    J.Mol.Cell.Cardiol., 2013;55:27
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