Chemical Name: 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
Biological ActivityPotent muscarinic DREADD agonist (pEC50 values are 8.38, 8.08 and 7.27 for hM1Dq, hM3Dq and hM4Di in vitro, respectively). Exhibits >10,000-fold selectivity for hM3Dq over hM3 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.
Chen et al.
ACS Chem.Neurosci., 2015;18:476
DREADD agonist 21 (C21) is an effective agonist for muscarinic-based DREADDs in vitro and in vivo.
Thompson et al.
ACS Pharmacol.Transl.Sci., 2018;
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