Perlapine

Catalog # Availability Size / Price Qty
5549/50
5549/10
Cat.No. 5549 - Perlapine | C19H21N3 | CAS No. 1977-11-3
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Description: Potent muscarinc DREADD agonist

Chemical Name: 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine

Product Details
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Biological Activity

Potent muscarinic DREADD agonist (pEC50 values are 8.38, 8.08 and 7.27 for hM1Dq, hM3Dq and hM4Di in vitro, respectively). Exhibits >10,000-fold selectivity for hM3Dq over hM3 receptors.

Technical Data

Formula:
C19H21N3
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in water with gentle warming
Storage:
Store the unopened product at room temperature. Do not use past expiration date.
CAS No:
1977-11-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.
    Chen et al.
    ACS Chem.Neurosci., 2015;18:476
  2. DREADD agonist 21 (C21) is an effective agonist for muscarinic-based DREADDs in vitro and in vivo.
    Thompson et al.
    ACS Pharmacol.Transl.Sci., 2018;

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