Caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.
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Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway.
Jiang et al.
Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
Nguyen and Wells