Chemical Name: α-(Trichloromethyl)-4-pyridineethanol
Biological ActivityPETCM is a caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway.
Jiang et al.
Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
Nguyen and Wells
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