Catalog Number: 1758
Chemical Name: α-(Trichloromethyl)-4-pyridineethanol
Biological Activity
Caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in 1eq. HCl
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway.
    Jiang et al.
    Science, 2003;299:223
  2. Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
    Nguyen and Wells
    Proc.Natl.Acad.Sci.U.S.A., 2003;100:7533
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