Catalog Number: 5915
Alternate Names: PF 9613
Chemical Name: 1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one
Biological Activity
Potent PDE9 inhibitor (IC50 = 22 nM). Also exhibits a high affinity for cGMP (Km = ~170 nM). Brain penetrant.
Technical Data
  • M.Wt:
    395.45
  • Formula:
    C21H25N5O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1236858-52-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
    Kleiman et al.
    J.Pharmacol.Exp.Ther., 2012;341:396
  2. Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
    Lee et al.
    Nature, 2015;519:472
  3. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.
    Claffey et al.
    J.Med.Chem., 2012;55:9055
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