PF 04449913 maleate
Chemical Name: 1-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate salt
Biological ActivityPotent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened.
Munchhof et al.
ACS Med.Chem.Lett., 2011;3:106
Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells.
Fukushima et al.
Cancer Sci., 2016;107:1422
The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells.
Giordani et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PF 04449913 maleate
There are currently no reviews for this product. Be the first to review PF 04449913 maleate and earn rewards!
Have you used PF 04449913 maleate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image