PF 04449913 maleate
Chemical Name: 1-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate salt
Biological ActivityPotent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened.
Munchhof et al.
ACS Med.Chem.Lett., 2011;3:106
Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells.
Fukushima et al.
Cancer Sci., 2016;107:1422
The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells.
Giordani et al.
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