PF 04457845

Key Product Details

Product Description

PF 04457845 is a potent and selective irreversible FAAH inhibitor (IC₅₀ = 7.2 nM, which is selective for FAAH over a panel of other serine hydrolases. PF 04457845 exhibits efficacy in a rat inflammatory pain model, and is orally bioavailable and brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

External Portal Information

Chemicalprobes.org

and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of PF 04457845 is reviewed on chemicalprobes.org and the SGC website.

Product Specifications for PF 04457845

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 04457845

The following data is based on the product molecular weight 455.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	10.98 mL	21.96 mL
5 mM	0.44 mL	2.20 mL	4.39 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Johnson Discovery of PF-04457845: a highly potent, orally bioavailable, and selective urea FAAH inhibitor. ACS Med.Chem.Lett. 2011 PMID: 21666860
• Ahn Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J.Pharmacol.Exp.Ther. 2011 PMID: 21505060

Product Documents for PF 04457845