PF 05175157

Key Product Details

Product Description

PF 05175157 is an potent acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC₅₀ values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 05175157

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 05175157

The following data is based on the product molecular weight 405.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.93 mL	24.66 mL	49.32 mL
2.5 mM	0.99 mL	4.93 mL	9.86 mL
5 mM	0.49 mL	2.47 mL	4.93 mL
25 mM	0.10 mL	0.49 mL	0.99 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Griffith Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes. J.Med.Chem. 2014 PMID: 25423286

Product Documents for PF 05175157