PF 05175157

Catalog # Availability Size / Price Qty
5790/10
5790/50
PF 05175157 | CAS No. 1301214-47-0 | Additional Lipid Metabolism Compounds
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Description: Acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor

Chemical Name: 1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

PF 05175157 is an acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable.

Technical Data

M.Wt:
405.49
Formula:
C23H27N5O2
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1301214-47-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citation for PF 05175157

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