PF 05180999

Tocris Bioscience | Catalog # 6405

Potent and selective PDE2A inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective PDE2A inhibitor
View all Phosphodiesterase Inhibitors »

Product Description

PF 05180999 is a potent and selective PDE2A inhibitor (IC50 = 1 nM). Exhibits 2000-fold selectivity for PDE2A over PDE10A. Brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 05180999

Molecular Weight

414.39

Formula

C19H17F3N8

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine

CAS Number

1394033-54-5

PubChem ID

60143346

InChI Key

CLGCHUKGBICQTE-UHFFFAOYSA-N

SMILES

CC1=NC(C2=C(C3=NC=C(C(F)(F)F)C=C3)N(C)N=C2)=C4N1N=CN=C4N5CCC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 50
Ethanol 20.72 50

Preparing Stock Solutions for PF 05180999

The following data is based on the product molecular weight 414.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.83 mL 24.13 mL 48.26 mL
2.5 mM 0.97 mL 4.83 mL 9.65 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
25 mM 0.10 mL 0.48 mL 0.97 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 05180999

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 05180999

For research use only

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