PF 05190457

Catalog # Availability Size / Price Qty
PF 05190457 | CAS No. 1334782-79-4 | Ghrelin Receptor Inverse Agonists
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Description: High affinity and selective ghrelin receptor inverse agonist

Chemical Name: 1-[2-[(1R)-2,3-Dihydro-5-(6-methyl-4-pyrimidinyl)-1H-inden-1-yl]-2,7-diazaspiro[3,5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

PF 05190457 is a high affinity and selective ghrelin receptor inverse agonist (Kd = 3 nM). Exhibits selectivity for ghrelin receptors over a panel of other targets. Increases intracellular Ca2+ concentration in and insulin secretion from human islets in vitro. Increases gastric afferent nerve activity in a rat ex vivo stomach preparation.

Technical Data

Soluble to 5 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc

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Citation for PF 05190457

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