PF 06260933 dihydrochloride

Catalog # Availability Size / Price Qty
PF 06260933 dihydrochloride | CAS No. 1883548-86-4 | HGK
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Description: MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK

Chemical Name: 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

PF 06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

Technical Data

Soluble to 100 mM in water and to 20 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment.
    Ammirati et al.
    ACS Med.Chem.Lett., 2015;6:1128

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Citation for PF 06260933 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PF 06260933 dihydrochloride include:

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