PF 06260933 dihydrochloride

Key Product Details

Product Description

PF 06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC₅₀ = 140 nM). Also inhibits MINK and TNIK (IC₅₀ values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 06260933 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 06260933 dihydrochloride

The following data is based on the product molecular weight 369.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.53 mL	27.05 mL
5 mM	0.54 mL	2.71 mL	5.41 mL
10 mM	0.27 mL	1.35 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ammirati Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment. ACS Med.Chem.Lett. 2015 PMID: 26617966

Product Documents for PF 06260933 dihydrochloride