MAP4K4 (HGK) inhibitor (IC50
= 140 nM). Also inhibits MINK and TNIK (IC50
values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment.
Ammirati et al.
ACS Med.Chem.Lett., 2015;6:1128