PF 06260933 dihydrochloride

Catalog # Availability Size / Price Qty
5752/10
5752/50
Cat.No. 5752 - PF 06260933 dihydrochloride | C16H13ClN4.2HCl
1 Image
Description: MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK

Chemical Name: 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

Technical Data

M.Wt:
369.68
Formula:
C16H13ClN4.2HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment.
    Ammirati et al.
    ACS Med.Chem.Lett., 2015;6:1128

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for PF 06260933 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PF 06260933 dihydrochloride include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PF 06260933 dihydrochloride

There are currently no reviews for this product. Be the first to review PF 06260933 dihydrochloride and earn rewards!

Have you used PF 06260933 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.