PF 06260933 dihydrochloride
Chemical Name: 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride
Biological ActivityMAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment.
Ammirati et al.
ACS Med.Chem.Lett., 2015;6:1128
Citation for PF 06260933 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PF 06260933 dihydrochloride include:
1 Citation: Showing 1 - 1
MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.
Authors: Gao Et al.
Mol Oncol 2017;11:628
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