PF 06424439

Tocris Bioscience | Catalog # 6348

Potent and selective DGAT2 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective DGAT2 inhibitor
View all Diacylglycerol O-Acyltransferase (DGAT) Inhibitors »

Product Description

PF 06424439 is a potent and selective DGAT2 inhibitor (IC50 = 14 nM). Exhibits no significant activity at MGAT1-3 or DGAT1. Reduces triglyderide synthesis in human hepatocytes in vitro. Reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 06424439

Molecular Weight

536.05

Formula

C22H26ClN7O.CH4O3S

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate

CAS Number

1469284-79-4

PubChem ID

89854212

InChI Key

ZSTFDNQQOJUJFL-XFULWGLBSA-N

SMILES

ClC(C=N1)=CN1C2(CC2)C3=NC4=CC=C(N5C[C@H](C(N6CCCC6)=O)CCC5)N=C4N3.O=S(C)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 53.6 100
DMSO 53.6 100

Preparing Stock Solutions for PF 06424439

The following data is based on the product molecular weight 536.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.33 mL 18.65 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for PF 06424439

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 06424439

For research use only

Customer Reviews for PF 06424439 (1)

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  • Works great!
    Name: Qing Li
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: BMDM
    Verified Customer | Posted 10/19/2022
    I incubated BMDM with this inhibitor, it reduced the lipid level. Works great!
    PF 06424439 6348

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