Home / Diacylglycerol O-Acyltransferase (DGAT) Inhibitors / PF 06424439

PF 06424439

Catalog #: 6348 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6348/5
PF 06424439 | CAS No. 1469284-79-4 | Diacylglycerol O-Acyltransferase (DGAT) Inhibitors
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Description: Potent and selective DGAT2 inhibitor

Chemical Name: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate

Purity: ≥98%

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Biological Activity

PF 06424439 is a potent and selective DGAT2 inhibitor (IC50 = 14 nM). Exhibits no significant activity at MGAT1-3 or DGAT1. Reduces triglyderide synthesis in human hepatocytes in vitro. Reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Orally bioavailable.

Technical Data

M.Wt:
536.05
Formula:
C22H26ClN7O.CH4O3S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1469284-79-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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