PF 06465469

Catalog # Availability Size / Price Qty
4710/10
4710/50
Cat.No. 4710 - PF 06465469 | C30H33N7O2 | CAS No. 1407966-77-1
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Description: Potent ITK inhibitor; also inhibits BTK

Chemical Name: (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide

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Biological Activity

Potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50 = 2 nM). Also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50 = 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50 values are 31 and 48 nM respectively).

Technical Data

Formula:
C30H33N7O2
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
1407966-77-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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