PF 06465469

Tocris Bioscience | Catalog # 4710

Potent ITK inhibitor; also inhibits BTK
Tocris Bioscience

Key Product Details

Description

Potent ITK inhibitor; also inhibits BTK
View all ITK Inhibitors »

Product Description

PF 06465469 is a potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50 = 2 nM). Also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50 = 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50 values are 31 and 48 nM respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 06465469

Molecular Weight

523.63

Formula

C30H33N7O2

Storage

Store at +4°C

Purity

≥95% (HPLC)

Chemical Name

(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide

CAS Number

1407966-77-1

PubChem ID

71450146

InChI Key

CGJVMKJGKFEHTL-HSZRJFAPSA-N

SMILES

NC1=C2C(N([C@@H]4CCCN(C(C=C)=O)C4)N=C2C3=CC(C(NC5=CC(C)=C(C(C)C)C=C5)=O)=CC=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.62 5 with gentle warming

Preparing Stock Solutions for PF 06465469

The following data is based on the product molecular weight 523.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 38.19 mL 190.97 mL 381.95 mL
0.25 mM 7.64 mL 38.19 mL 76.39 mL
0.5 mM 3.82 mL 19.10 mL 38.19 mL
2.5 mM 0.76 mL 3.82 mL 7.64 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for PF 06465469

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 06465469

For research use only

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