Potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50
= 2 nM). Also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50
= 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50
values are 31 and 48 nM respectively).
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All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Covalent inhibitors of interleukin-2 inducible T cell kinase (Itk) with nanomolar potency in a whole-blood assay.
Zapf et al.