PF 06551600 malonate

Tocris Bioscience | Catalog # 6506

Potent and selective JAK3 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective JAK3 inhibitor
View all JAK Kinase Inhibitors »

Product Description

PF 06551600 malonate is a potent and selective JAK3 inhibitor (IC50 = 33.1 μM). Exhibits no significant activity against a panel of other kinases including JAK1, JAK2 and TYK2. Inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. Suppresses Th1 and Th17 T-cell differentiation and function in vitro. Reduces paw swelling in a rat model of arthritis and reduces disease severity in a rat EAE model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 06551600 malonate

Molecular Weight

389.41

Formula

C15H19N5O.C3H4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate

CAS Number

2140301-97-7

PubChem ID

124203830

InChI Key

QMPMPSGDPRHZCG-VZXYPILPSA-N

SMILES

C[C@H]1CC[C@@H](NC2=C3C=CNC3=NC=N2)CN1C(C=C)=O.OC(CC(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 38.94 100
DMSO 38.94 100

Preparing Stock Solutions for PF 06551600 malonate

The following data is based on the product molecular weight 389.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for PF 06551600 malonate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 06551600 malonate

For research use only

Citations for PF 06551600 malonate

Customer Reviews for PF 06551600 malonate (1)

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  • Works well for JAK inhibitor.
    Name: Scott Scarneo
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: THP-1 Cells
    Verified Customer | Posted 08/07/2019
    To test the effects of this inhibitor on TNF production in stimulated THP-1 cells.
    PF 06551600 malonate 6506

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