-secretase inhibitor (IC50
values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ
in brain, CSF and plasma in mice and guinea pigs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.
Lanz et al.