PF 3084014 hydrobromide

Key Product Details

Product Description

PF 3084014 hydrobromide is a potent γ-secretase inhibitor (IC₅₀ values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 3084014 hydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 3084014 hydrobromide

The following data is based on the product molecular weight 651.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.53 mL	7.67 mL	15.35 mL
5 mM	0.31 mL	1.53 mL	3.07 mL
10 mM	0.15 mL	0.77 mL	1.53 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lanz Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 2010 PMID: 20363853

Product Documents for PF 3084014 hydrobromide