PF 3644022

  ( 2 citations )    
Product Datasheet
Catalog Number:4279
Chemical Name:(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
Product Details
Citations (2)
Reviews
Biological Activity
Potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 3644022 is reviewed on the chemical probes website..
Technical Data
  • M.Wt:
    374.46
  • Formula:
    C21H18N4OS
  • Solubility:
    Soluble to 40 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1276121-88-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PF 3644022 include:

2 Citations: Showing 1 - 2
Filter your results:

  1. MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
    Authors: Jaco Et al.
    Mol Cell  2017;66:698
  2. Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells.
    Authors: Lingelem Et al.
    PLoS One  2015;10:e0129214

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used PF 3644022?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee