PF 3644022

Catalog # Availability Size / Price Qty
4279/10
PF 3644022 | CAS No. 1276121-88-0 | MAPK Inhibitors
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Description: Potent MK2 inhibitor

Chemical Name: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

Potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 3644022 is reviewed on the chemical probes website..

Technical Data

M.Wt:
374.46
Formula:
C21H18N4OS
Solubility:
Soluble to 40 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1276121-88-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PF 3644022

The citations listed below are publications that use Tocris products. Selected citations for PF 3644022 include:

4 Citations: Showing 1 - 4

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