Chemical Name: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
Biological ActivityPotent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Citations for PF 3644022
The citations listed below are publications that use Tocris products. Selected citations for PF 3644022 include:
5 Citations: Showing 1 - 5
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Authors: Bouhaddou Et al.
K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation.
Authors: Tang Et al.
Nat Commun 2019;10:4157
Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro.
Authors: Singh Et al.
Hum Exp Toxicol 2018;37:521
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
Authors: Jaco Et al.
Mol Cell 2017;66:698
Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells.
Authors: Lingelem Et al.
PLoS One 2015;10:e0129214
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