PF 3758309 dihydrochloride

Tocris Bioscience | Catalog # 6005

Potent PAK4 inhibitor; orally available
Tocris Bioscience

Key Product Details

Description

Potent PAK4 inhibitor; orally available
View all PAK Inhibitors »

Product Description

PF 3758309 dihydrochloride is a potent PAK4 inhibitor (IC50 = 1.3 nM; Kd = 2.7 nM). Inhibits proliferation and anchorage-independent growth of a panel of tumor cell lines in vitro. Suppresses growth of human HCT116 and A549 tumor cell xenografts in mice. Orally available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 3758309 is reviewed on the Chemical Probes website.

Product Specifications for PF 3758309 dihydrochloride

Molecular Weight

563.55

Formula

C25H30N8OS.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride

PubChem ID

91885498

InChI Key

BTVSNRMSUYBDRT-JQDLGSOUSA-N

SMILES

CN(C[C@H](C1=CC=CC=C1)NC(N2CC3=C(C2(C)C)NN=C3NC4=C5SC=CC5=NC(C)=N4)=O)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 56.35 100
DMSO 56.35 100

Preparing Stock Solutions for PF 3758309 dihydrochloride

The following data is based on the product molecular weight 563.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.87 mL 17.74 mL
5 mM 0.35 mL 1.77 mL 3.55 mL
10 mM 0.18 mL 0.89 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 3758309 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 3758309 dihydrochloride

For research use only

Related Research Areas

Intracellular Kinases

Citations for PF 3758309 dihydrochloride

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