8 results for "PAK Inhibitors" in Products
PAK Inhibitors
P21-activated kinases (PAKs), EC 2.7.11.1, are serine/threonine kinases that are effector proteins for the Rho GTPases Cdc42 and Rac. Six PAK isoforms have been identified to date, which can be split into two groups: group I - PAK1, PAK2 and PAK3; and group II - PAK4, PAK5 and PAK6. The PAK isoforms have varying levels of expression and tissue distribution, although they are all highly expressed in the nervous system.
Group A PAKs exist as homodimers in their inactive state, where their ...
Group I PAK inhibitor
| Chemical Name: | 1,1'-Dithiodi-2-naphthtol |
| Purity: | ≥96% |
Potent PAK inhibitor; brain penetrant and orally bioavailable
| Chemical Name: | 6-(2,4-Dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one |
| Purity: | ≥98% |
Potent PAK4 inhibitor; orally available
| Chemical Name: | N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride |
| Purity: | ≥98% |
Potent group I PAK inhibitor
| Chemical Name: | 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one |
| Purity: | ≥98% |
High affinity group I PAK inhibitor
| Chemical Name: | 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Purity: | ≥98% |
Potent and selective PAK1 inhibitor
| Chemical Name: | (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide |
| Purity: | ≥98% |
Negative control of NVS PAK1 1 (Cat. No. 6132)
| Chemical Name: | (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide |
| Purity: | ≥98% |
Highly potent PAK1 and PAK2 inhibitor
| Chemical Name: | 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile |
| Purity: | ≥98% |
