Chemical Name: N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
Biological ActivityPF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders.
Ahn et al.
Expert Opin.Drug Discov., 2009;4:763
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Ahn et al.
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