Catalog Number: 4175
Chemical Name: N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
Biological Activity
Selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).
Technical Data
  • M.Wt:
    456.46
  • Formula:
    C24H23F3N4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1196109-52-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
    Ahn et al.
    Chem.Biol., 2009;16:411
  2. Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders.
    Ahn et al.
    Expert Opin.Drug Discov., 2009;4:763

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