Dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50
values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.
Soluble to 50 mM in DMSO
Store at +4°C
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Sold for research purposes under agreement from Pfizer Inc.
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.
Buckbinder et al.
Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
Han et al.
Emerging targets in osteoporosis disease modification.
Allen et al.
The citations listed below are publications that use Tocris products. Selected citations for PF 431396 include:
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