PF 431396

Key Product Details

Product Description

PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC₅₀ values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 431396

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 431396

The following data is based on the product molecular weight 506.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.95 mL	19.74 mL	39.49 mL
2.5 mM	0.79 mL	3.95 mL	7.90 mL
5 mM	0.39 mL	1.97 mL	3.95 mL
25 mM	0.08 mL	0.39 mL	0.79 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

• Han Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem. 2009 PMID: 19244237
• Allen Emerging targets in osteoporosis disease modification. J.Med.Chem. 2010 PMID: 20218623
• Buckbinder Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc.Natl.Acad.Sci.USA 2007 PMID: 17537919

Product Documents for PF 431396