Chemical Name: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
Biological ActivityHigh affinity and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Citation for PF 514273
The citations listed below are publications that use Tocris products. Selected citations for PF 514273 include:
1 Citation: Showing 1 - 1
AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.
Authors: Rozenfeld Et al.
EMBO J 2011;30:2350
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Used in vivo for mouse behavioral work to test CB1 receptor involvement in alcohol reward learning and seeking behavior. Data show product did work centrally, as it reduced locomotor activity.