Potent and selective CB1
receptor antagonist (Ki
values are 1 and > 10000 nM at CB1
receptors respectively). Inhibits food intake in vivo
following oral administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazole[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of
Dow et al.
The citations listed below are publications that use Tocris products. Selected citations for PF 514273 include:
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