Catalog Number: 3676
Chemical Name: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
Biological Activity
Potent and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.
Technical Data
  • M.Wt:
    452.28
  • Formula:
    C21H17Cl2F2N3O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    851728-60-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazole[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of
    Dow et al.
    J.Med.Chem., 2009;52:2652
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PF 514273 include:

1 Citations: Showing 1 - 1

  1. AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.
    Authors: Rozenfeld Et al.
    EMBO J 2011;30:2350

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