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PFI 3 | CAS No. 1819363-80-8 | Bromodomain Inhibitors
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Description: Potent and selective SMARCA2/4 and polybromo 1 inhibitor

Chemical Name: (2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one

Purity: ≥98%

Product Details
Citations (2)

Biological Activity

PFI 3 is a potent and selective polybromo 1 (PBRM1) and SMARCA4 inhibitor (Kd values are 48 and 89 nM respectively) that also inhibits SMARCA2. This compoud displays 30-fold selectivity over other sub-family branches. PFI 3 accelerates FRAP recovery in cells at a concentration of 1 μM.

External Portal Information is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PFI 3 is reviewed on the chemical probes website.

Technical Data

Soluble to 100 mM in DMSO and to 5 mM in ethanol with gentle warming
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the PFI 3 probe summary on the SGC website.

Product Datasheets

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Citations for PFI 3

The citations listed below are publications that use Tocris products. Selected citations for PFI 3 include:

2 Citations: Showing 1 - 2


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