PFK 15

Catalog # Availability Size / Price Qty
5339/10
5339/50
Cat.No. 5339 - PFK 15 | C17H12N2O | CAS No. 4382-63-2
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Description: Selective PFKFB3 inhibitor

Chemical Name: 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one

Purity: ≥99%

Product Details
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Biological Activity

Originally reported to be a selective PFKFB3 inhibitor (IC50 = 207 nM); a more recent report failed to demonstrate activity in a PFKFB3 kinase assay. Selective for PFKFB3 over a panel of 96 kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits metastasis of Lewis lung carcinoma cell xenografts in mice.

Technical Data

M.Wt:
260.29
Formula:
C17H12N2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
4382-63-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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