PFM 01

Tocris Bioscience | Catalog # 6222

MRE11 endonuclease inhibitor
Tocris Bioscience
Discontinued Product
6222 has been discontinued. View all Endonuclease Inhibitors products.

Key Product Details

Description

MRE11 endonuclease inhibitor
View all Endonuclease Inhibitors »

Product Description

PFM 01 is a MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.

Product Specifications for PFM 01

Molecular Weight

293.40

Formula

C14H15NO2S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone

CAS Number

1558598-41-6

PubChem ID

2145809

InChI Key

GPURHDUTZUYAFI-GHXNOFRVSA-N

SMILES

CC(CN1C(S/C(C1=O)=C\C2=CC=C(C=C2)O)=S)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.34 100
Ethanol 29.34 100

Preparing Stock Solutions for PFM 01

The following data is based on the product molecular weight 293.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.04 mL 34.08 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.70 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for PFM 01

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PFM 01

For research use only

Related Research Areas

Base Excision Repair

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