Catalog Number: 5094
Biological Activity
Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.
Technical Data
  • M.Wt:
    1180.41
  • Formula:
    C59H85N15O11
  • Sequence:
    XDPFRWKPV

    (Modifications: X-1 = Ac-Nle, Phe-4 = D-Phe, Val-9 = C-terminal amide, Asp-2, Lys-7, Cyclized)

  • Solubility:
    Soluble to 2 mg/ml in 25% ethanol / water
  • Storage:
    Store at -20°C
  • CAS No:
    667430-81-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage.
    Giuliani et al.
    Br.J.Pharmacol., 2007;150:595
  2. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
    Grieco et al.
    J.Pept.Res., 2003;62:199

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