Potent and selective melanocortin 4 (MC4
) receptor agonist (IC50
values are 0.58 and 55 nM for human MC4
receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.
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Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage.
Giuliani et al.
Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
Grieco et al.