PG 931
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Description: Potent and selective MC4 receptor agonist
Biological Activity
PG 931 is a potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.Technical Data
M.Wt:
1180.41
Formula:
C59H85N15O11
Sequence:
XDPFRWKPV
(Modifications: X-1 = Ac-Nle, Phe-4 = D-Phe, Val-9 = C-terminal amide, Asp-2, Lys-7, Cyclized)
Solubility:
Soluble to 2 mg/ml in 25% ethanol / water
Storage:
Store at -20°C
CAS No:
667430-81-1
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage.
Giuliani et al.
Br.J.Pharmacol., 2007;150:595 -
Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
Grieco et al.
J.Pept.Res., 2003;62:199
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