Biological ActivityPhalloidin is a promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.
ATCXAWL (Modifications: Cyclic Cys-3-Trp-6, X=Hyp, D-Thr-2)
Soluble to 1 mg/ml in water
Store at -20°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin.
Diensthuber et al.
FEBS Lett., 2011;585:767
Effects of cytochalasin and phalloidin on actin.
J.Cell Biol., 1987;105:1473
Phalloidin enhances actin assembly by preventing monomer dissociation.
Coluccio and Tilney
J.Cell Biol., 1984;99:529
Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth.
Wehland et al.
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