Phalloidin
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Description: Promotes actin polymerization
Biological Activity
Phalloidin is a promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.Technical Data
M.Wt:
788.87
Formula:
C35H48N8O11S
Sequence:
ATCXAWL (Modifications: Cyclic Cys-3-Trp-6, X=Hyp, D-Thr-2)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
17466-45-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin.
Diensthuber et al.
FEBS Lett., 2011;585:767 -
Effects of cytochalasin and phalloidin on actin.
Cooper
J.Cell Biol., 1987;105:1473 -
Phalloidin enhances actin assembly by preventing monomer dissociation.
Coluccio and Tilney
J.Cell Biol., 1984;99:529 -
Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth.
Wehland et al.
Proc.Natl.Acad.Sci.USA, 1977;74:5613
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