Biological ActivityPhalloidin is a promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.
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Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin.
Diensthuber et al.
FEBS Lett., 2011;585:767
Effects of cytochalasin and phalloidin on actin.
J.Cell Biol., 1987;105:1473
Phalloidin enhances actin assembly by preventing monomer dissociation.
Coluccio and Tilney
J.Cell Biol., 1984;99:529
Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth.
Wehland et al.
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