Inhibitor of Na+
-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.
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Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
Rossetti et al.
Phlorizin: a review.
Ehrenkranz et al.
Diabetes Metab Res Rev., 2005;21:31
Renal Na+-glucose cotransporters.