Phlorizin

Catalog # Availability Size / Price Qty
4627/50
Phlorizin | CAS No. 60-81-1 | Other Ion Pump/Transporter Inhibitors
1 Image
Description: Na+-glucose cotransporter (SGLT) inhibitor

Chemical Name: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone

Purity: ≥99%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.

Technical Data

M.Wt:
436.41
Formula:
C21H24O10
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
60-81-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to Ins in diabetic rats.
    Rossetti et al.
    J.Clin.Invest., 1987;79:1510
  2. Phlorizin: a review.
    Ehrenkranz et al.
    Diabetes Metab Res Rev., 2005;21:31
  3. Renal Na+-glucose cotransporters.
    Wright
    Am.J.Physiol.Renal.Physiol., 2001;280:F10

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Citation for Phlorizin

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Phlorizin inhibits LPS-induced iNOS in HL-1 cells
By Chintan Koyani on 10/22/2018
Species: Mouse

HL-1 cardiomyocytes were stimulated with Phlorizin (0-200 µM) alone or in combination with LPS (1 µg/ml) for 8 h to follow iNOS expression by Western blot. Phlorizin inhibited LPS-induced iNOS expression starting from 100 µM concentration (shown in Image).


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