Chemical Name: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
Biological ActivityInhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to Ins in diabetic rats.
Rossetti et al.
Phlorizin: a review.
Ehrenkranz et al.
Diabetes Metab Res Rev., 2005;21:31
Renal Na+-glucose cotransporters.
Citation for Phlorizin
The citations listed below are publications that use Tocris products. Selected citations for Phlorizin include:
1 Citation: Showing 1 - 1
T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.
Authors: Smith Et al.
Mol Metab 2018;17:98
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HL-1 cardiomyocytes were stimulated with Phlorizin (0-200 µM) alone or in combination with LPS (1 µg/ml) for 8 h to follow iNOS expression by Western blot. Phlorizin inhibited LPS-induced iNOS expression starting from 100 µM concentration (shown in Image).