Phlorizin

Tocris Bioscience | Catalog # 4627

Na+-glucose cotransporter (SGLT) inhibitor
Tocris Bioscience
Discontinued Product
4627 has been discontinued. View all Other Ion Pump/Transporter Inhibitors products.

Key Product Details

Description

Na+-glucose cotransporter (SGLT) inhibitor
View all Other Ion Pump/Transporter Inhibitors »

Product Description

Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.

Product Specifications for Phlorizin

Molecular Weight

436.41

Formula

C21H24O10

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone

CAS Number

60-81-1

PubChem ID

6072

InChI Key

IOUVKUPGCMBWBT-QNDFHXLGSA-N

SMILES

O=C(CCC2=CC=C(O)C=C2)C1=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.64 100
Ethanol 43.64 100

Preparing Stock Solutions for Phlorizin

The following data is based on the product molecular weight 436.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.46 mL 22.91 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for Phlorizin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Phlorizin

For research use only

Customer Reviews for Phlorizin (1)

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  • Phlorizin inhibits LPS-induced iNOS in HL-1 cells
    Name: Chintan Koyani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: cardiomyocytes
    Verified Customer | Posted 10/22/2018
    HL-1 cardiomyocytes were stimulated with Phlorizin (0-200 µM) alone or in combination with LPS (1 µg/ml) for 8 h to follow iNOS expression by Western blot. Phlorizin inhibited LPS-induced iNOS expression starting from 100 µM concentration (shown in Image).
    Phlorizin 4627

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