Catalog Number: 4627
Chemical Name: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
Biological Activity
Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
    Rossetti et al.
    J.Clin.Invest., 1987;79:1510
  2. Phlorizin: a review.
    Ehrenkranz et al.
    Diabetes Metab Res Rev., 2005;21:31
  3. Renal Na+-glucose cotransporters.
    Am.J.Physiol.Renal.Physiol., 2001;280:F10
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