Phorbol 12-myristate 13-acetate

  ( 23 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1201
Alternate Names:PMA
Chemical Name:(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a- (Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate
Product Details
Citations (23)
Reviews
Biological Activity
Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a Ki value of 2.6 nM as measured by displacement of [3H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.
Technical Data
  • M.Wt:
    616.83
  • Formula:
    C36H56O8
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at -20°C
  • CAS No:
    16561-29-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12-myristate 13-acetate include:

23 Citations: Showing 1 - 10
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  1. Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tatprotein-inhibited dopamine transport.
    Authors: Quizon
    Scientific Reports  2016;6:39048
  2. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.
    Authors: Brust Et al.
    J Vis Exp  2015;93:85
  3. Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays.
    Authors: Hagen Et al.
    Cells  2015;4:84
  4. Levitational Image Cytometry with Temporal Resolution.
    Authors: Tasoglu Et al.
    Adv Mater  2015;27:3901
  5. The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene.
    Authors: Davis
    Biochem Pharmacol  2015;12:847
  6. Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses.
    Authors: Bemben Et al.
    Proc Natl Acad Sci U S A  2015;112:2551
  7. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
    Authors: Brown Et al.
    J Pharmacol Exp Ther  2014;88:13149
  8. Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells.
    Authors: Yu Et al.
    J Exp Clin Cancer Res  2014;33:85
  9. The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation.
    Authors: Walsh Et al.
    Redox Biol  2014;2:178
  10. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.
    Authors: Li Et al.
    Cell Signal  2014;26:1369
  11. Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.
    Authors: Baba Et al.
    Sci Signal  2013;6:ra89
  12. The analysis of purkinje cell dendritic morphology in organotypic slice cultures.
    Authors: Kapfhammer and Gugger
    J Biol Chem  2012;NULL
  13. Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse.
    Authors: Gao Et al.
    J Virol  2012;61:1381
  14. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
    Authors: Kaszás Et al.
    J Neurosci  2012;340:152
  15. Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells.
    Authors: Sakata Et al.
    Am J Physiol Endocrinol Metab  2012;302:E1300
  16. The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.
    Authors: Gabriel Et al.
    J Biol Chem  2012;287:32354
  17. Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice.
    Authors: Zsombok Et al.
    Curr Alzheimer Res  2011;31:14024
  18. The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking.
    Authors: Navaroli Et al.
    J Neurosci  2011;31:13758
  19. Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C.
    Authors: Specht Et al.
    EMBO J  2011;30:3842
  20. Involvement of the chemokine-like receptor GPR33 in innate immunity.
    Authors: Bohnekamp Et al.
    Br J Pharmacol  2010;396:272
  21. Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response.
    Authors: Nishida Et al.
    Nucleic Acids Res  2009;37:5678
  22. Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.
    Authors: Jones Et al.
    Biochem Biophys Res Commun  2004;279:40475
  23. Nifedipine facilitates neurotransmitter release independently of calcium channels.
    Authors: Hirasawa
    Proc Natl Acad Sci U S A  2003;100:6139
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 PMA stimulation of lymphocytes 1201 Array 1201
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  Mouse Anonymous 01/25/2018
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 PMA stimulation of lymphocytes 1201
: PMA stimulation of lymphocytes [1201].

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