Phorbol 12-myristate 13-acetate
Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a- (Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate
Biological ActivityExtensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a Ki value of 2.6 nM as measured by displacement of [3H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
Castagna et al.
A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation.
Hockberger et al.
Structural determinants of phorbol ester binding in synaptosomes: pharmacokinetics and pharmacodynamics.
Murphy et al.
Citations for Phorbol 12-myristate 13-acetate
The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12-myristate 13-acetate include:
23 Citations: Showing 1 - 10
Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tatprotein-inhibited dopamine transport.
Scientific Reports 2016;6:39048
New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.
Authors: Brust Et al.
J Vis Exp 2015;93:85
Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays.
Authors: Hagen Et al.
Levitational Image Cytometry with Temporal Resolution.
Authors: Tasoglu Et al.
Adv Mater 2015;27:3901
The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene.
Biochem Pharmacol 2015;12:847
Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses.
Authors: Bemben Et al.
Proc Natl Acad Sci U S A 2015;112:2551
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
J Pharmacol Exp Ther 2014;88:13149
Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells.
Authors: Yu Et al.
J Exp Clin Cancer Res 2014;33:85
The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation.
Authors: Walsh Et al.
Redox Biol 2014;2:178
PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.
Authors: Li Et al.
Cell Signal 2014;26:1369
Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.
Authors: Baba Et al.
Sci Signal 2013;6:ra89
The analysis of purkinje cell dendritic morphology in organotypic slice cultures.
Authors: Kapfhammer and Gugger
J Biol Chem 2012;NULL
Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse.
Authors: Gao Et al.
J Virol 2012;61:1381
Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
Authors: Kaszás Et al.
J Neurosci 2012;340:152
Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells.
Authors: Sakata Et al.
Am J Physiol Endocrinol Metab 2012;302:E1300
The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.
Authors: Gabriel Et al.
J Biol Chem 2012;287:32354
Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice.
Authors: Zsombok Et al.
Curr Alzheimer Res 2011;31:14024
The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking.
Authors: Navaroli Et al.
J Neurosci 2011;31:13758
Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C.
Authors: Specht Et al.
EMBO J 2011;30:3842
Involvement of the chemokine-like receptor GPR33 in innate immunity.
Authors: Bohnekamp Et al.
Br J Pharmacol 2010;396:272
Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response.
Authors: Nishida Et al.
Nucleic Acids Res 2009;37:5678
Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.
Authors: Jones Et al.
Biochem Biophys Res Commun 2004;279:40475
Nifedipine facilitates neurotransmitter release independently of calcium channels.
Proc Natl Acad Sci U S A 2003;100:6139
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