Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a Ki
value of 2.6 nM as measured by displacement of [3
H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
Castagna et al.
A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation.
Hockberger et al.
Structural determinants of phorbol ester binding in synaptosomes: pharmacokinetics and pharmacodynamics.
Murphy et al.
The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12-myristate 13-acetate include:
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