Phorbol 12-myristate 13-acetate

Catalog # Availability Size / Price Qty
Protein Kinase C Activators Small Molecule
1 Image
Description: Protein kinase C activator
Alternative Names: PMA

Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate

Purity: ≥99%

Product Details
Citations (23)
Reviews (1)

Biological Activity

Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a Ki value of 2.6 nM as measured by displacement of [3H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Phorbol 12-myristate 13-acetate

The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12-myristate 13-acetate include:

23 Citations: Showing 1 - 10

  1. Molecular mechanism: the human DA transporter histidine 547 regulates basal and HIV-1 Tatprotein-inhibited DA transport.
    Authors: Quizon
    Scientific Reports  2016;6:39048
  2. New functional activity of aripiprazole revealed: Robust antagonism of D2 DA receptor-stimulated Gβγ signaling.
    Authors: Brust Et al.
    J Vis Exp  2015;93:85
  3. Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays.
    Authors: Hagen Et al.
    Cells  2015;4:84
  4. Levitational Image Cytometry with Temporal Resolution.
    Authors: Tasoglu Et al.
    Adv Mater  2015;27:3901
  5. The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene.
    Authors: Davis
    Biochem Pharmacol  2015;12:847
  6. Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses.
    Authors: Bemben Et al.
    Proc Natl Acad Sci U S A  2015;112:2551
  7. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
    Authors: Brown Et al.
    J Pharmacol Exp Ther  2014;88:13149
  8. Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells.
    Authors: Yu Et al.
    J Exp Clin Cancer Res  2014;33:85
  9. The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation.
    Authors: Walsh Et al.
    Redox Biol  2014;2:178
  10. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.
    Authors: Li Et al.
    Cell Signal  2014;26:1369
  11. Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.
    Authors: Baba Et al.
    Sci Signal  2013;6:ra89
  12. The analysis of purkinje cell dendritic morphology in organotypic slice cultures.
    Authors: Kapfhammer and Gugger
    J Biol Chem  2012;NULL
  13. Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse.
    Authors: Gao Et al.
    J Virol  2012;61:1381
  14. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
    Authors: Kaszás Et al.
    J Neurosci  2012;340:152
  15. Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells.
    Authors: Sakata Et al.
    Am J Physiol Endocrinol Metab  2012;302:E1300
  16. The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.
    Authors: Gabriel Et al.
    J Biol Chem  2012;287:32354
  17. Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice.
    Authors: Zsombok Et al.
    Curr Alzheimer Res  2011;31:14024
  18. The plasma membrane-associated GTPase Rin interacts with the DA transporter and is required for protein kinase C-regulated DA transporter trafficking.
    Authors: Navaroli Et al.
    J Neurosci  2011;31:13758
  19. Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C.
    Authors: Specht Et al.
    EMBO J  2011;30:3842
  20. Involvement of the chemokine-like receptor GPR33 in innate immunity.
    Authors: Bohnekamp Et al.
    Br J Pharmacol  2010;396:272
  21. Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response.
    Authors: Nishida Et al.
    Nucleic Acids Res  2009;37:5678
  22. Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.
    Authors: Jones Et al.
    Biochem Biophys Res Commun  2004;279:40475
  23. Nifedipine facilitates neurotransmitter release independently of calcium channels.
    Authors: Hirasawa
    Proc Natl Acad Sci U S A  2003;100:6139


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PMA stimulation of lymphocytes
By Anonymous on 01/25/2018
Species: Mouse

50 ng/ml PMA used to stimulate cells isolated from mesenteric lymphnodes, followed by staining for IL-17A

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