Catalog Number: 4995
Chemical Name: (2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride
Biological Activity
Prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Induces expression of CYP1A1 and generates adducts in the DNA of sensitive MCF7 and IGROV-1 cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.
    Leong et al.
    Br.J.Cancer, 2003;88:470
  2. In vitro, in vivo and in silico analyses of the antitumor activity of 2(-4-amino-3-methylphenyl)-5-fluorobenzothiazoles.
    Leong et al.
    Mol.Cancer Ther., 2004;3:1565
  3. DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated by aryl hydrocarbon receptor deficient MCF-7 cells.
    Trapani et al.
    Br.J.Cancer, 2003;88:599
  4. The development of the antitumour benzothiazole prodrug, phortress, as a clinical candidate.
    Bradshaw and Westwell
    Curr.Med.Chem., 2004;11:1241
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