Chemical Name: (2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride
Biological ActivityPhortress is a prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Induces expression of CYP1A1 and generates adducts in the DNA of sensitive MCF7 and IGROV-1 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.
Leong et al.
In vitro, in vivo and in silico analyses of the antitumor activity of 2(-4-amino-3-methylphenyl)-5-fluorobenzothiazoles.
Leong et al.
Mol.Cancer Ther., 2004;3:1565
DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated by aryl hydrocarbon receptor deficient MCF-7 cells.
Trapani et al.
The development of the antitumour benzothiazole prodrug, phortress, as a clinical candidate.
Bradshaw and Westwell
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