Phosphoramidon disodium salt
Chemical Name: N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt
Biological ActivityPhosphoramidon disodium salt is a neutral endopeptidase (neprilysin) inhibitor. Blocks degradation of amyloid β peptides and increases Aβ levels in rodents. Also blocks endothelin converting enzyme (ECE).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance.
Marr and Hafez
Front.Aging Neurosci., 2014;6:187
Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
Shirotani et al.
Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA.
Warner et al.
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