Phosphoramidon disodium salt

Tocris Bioscience | Catalog # 6333

Neutral endopeptidase and endothelin converting enzyme inhibitor
Tocris Bioscience

Key Product Details

Description

Neutral endopeptidase and endothelin converting enzyme inhibitor
View all Additional Synthetic Protease Inhibitors »

Product Description

Phosphoramidon disodium salt is a neutral endopeptidase (neprilysin) inhibitor. Blocks degradation of amyloid β peptides and increases Aβ levels in rodents. Also blocks endothelin converting enzyme (ECE).

Product Specifications for Phosphoramidon disodium salt

Molecular Weight

587.47

Formula

C23H32N3Na2O10P

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt

CAS Number

164204-38-0

PubChem ID

16219931

InChI Key

OQKHVXFOYFBMDJ-ODIUWQMJSA-L

SMILES

CC(C[C@@H](C(N[C@H](C(O[Na])=O)CC1=CNC2=CC=CC=C12)=O)NP(O[C@@H]3O[C@H]([C@@H]([C@H]([C@H]3O)O)O)C)(O[Na])=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 58.75 100

Preparing Stock Solutions for Phosphoramidon disodium salt

The following data is based on the product molecular weight 587.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.70 mL 8.51 mL 17.02 mL
5 mM 0.34 mL 1.70 mL 3.40 mL
10 mM 0.17 mL 0.85 mL 1.70 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for Phosphoramidon disodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Phosphoramidon disodium salt

For research use only

Citations for Phosphoramidon disodium salt

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