Biological ActivityPhrixotoxin 3 is a potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner.
(Modifications: Disulfide bridges: 2-17, 9-23, 16-30)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.
Bosmans et al.
Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea.
Ono et al.
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We studied the depolarizing shift in gating kinetics and blocking of the inward component of the sodium current by Phrixotoxin 3.