Biological ActivityPotent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner.
(Modifications: Disulfide bridges: 2-17,9-23,16-30)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.
Bosmans et al.
Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea.
Ono et al.
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