Catalog Number: 5919
Chemical Name: 6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
Biological Activity
Potent and selective PI 3-kinase p110δ inhibitor (IC50 = 5 nM; Ki = 1.5 nM). Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.
Technical Data
  • M.Wt:
    506.64
  • Formula:
    C27H31FN6OS
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    955977-50-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Targeting PI3K/Akt/mTOR signaling in cancer.
    Porta et al.
    Front.Oncol., 2014;4:64
  2. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
    Ali et al.
    Nature, 2014;510:407
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