PI 3065

Catalog # Availability Size / Price Qty
5919/10
5919/50
PI 3065 | CAS No. 955977-50-1 | PI 3-Kinase Inhibitors
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Description: Potent and selective PI 3-kinase p110δ inhibitor

Chemical Name: 6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine

Purity: ≥98%

Product Details
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Biological Activity

PI 3065 is a potent and selective PI 3-kinase p110δ inhibitor (IC50 = 5 nM; Ki = 1.5 nM). Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.

Technical Data

M.Wt:
506.64
Formula:
C27H31FN6OS
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
955977-50-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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