Piclamilast

Catalog # Availability Size / Price Qty
4525/10
4525/50

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Piclamilast | CAS No. 144035-83-6 | Phosphodiesterase Inhibitors
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Description: Potent and selective PDE4 inhibitor
Alternative Names: RP 73401

Chemical Name: 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM).

Technical Data

M.Wt:
381.25
Formula:
C18H18Cl2N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
144035-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Piclamilast

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