Chemical Name: α-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol
Biological ActivityPimonidazole is a hypoxia detection reagent. Labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.
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Notch2 signaling regulates the proliferation of murine bone marrow-derived mesenchymal stem/stromal cells via c-Myc expression.
Sato et al.
PLoS One, 2016;11:e0165946
Orally administered pimonidazole to label hypoxic tumor cells.
Bennewith et al.
Cancer Res., 2002;62:6827
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Glioblstoma patient derived cell line E2 was cultured in a 3D model for 21 days and the level of hypoxia in the spheres were measured following treatment with Pimonidazole.