Pimonidazole

Name: Pimonidazole
Brand: Tocris Bioscience
SKU: 6182
Price: 114 USD
Availability: InStock
Rating: 5 (1 reviews)

Tocris Bioscience | Catalog # 6182

(1)

Citations (1)

Product Documents

Hypoxia detection reagent

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Hypoxia detection reagent

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Product Description

Pimonidazole is a hypoxia detection reagent. Labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.

Product Specifications for Pimonidazole

Molecular Weight

254.29

Formula

C₁₁H₁₈N₄O₃

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

α-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol

CAS Number

70132-50-2

PubChem ID

50981

InChI Key

WVWOOAYQYLJEFD-UHFFFAOYSA-N

SMILES

OC(CN1CCCCC1)CN2C=CN=C2[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.43	100
	Ethanol	25.43	100

Preparing Stock Solutions for Pimonidazole

The following data is based on the product molecular weight 254.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.93 mL	19.66 mL	39.33 mL
5 mM	0.79 mL	3.93 mL	7.87 mL
10 mM	0.39 mL	1.97 mL	3.93 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product.

Bennewith Orally administered pimonidazole to label hypoxic tumor cells. Cancer Res. 2002 PMID: 12460894
Sato Notch2 signaling regulates the proliferation of murine bone marrow-derived mesenchymal stem/stromal cells via c-Myc expression. PLoS One 2016 PMID: 27855169

Product Documents for Pimonidazole

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Pimonidazole

For research use only

Citations for Pimonidazole

Customer Reviews for Pimonidazole (1)

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PIMO detects the levels of hypoxia in Glioblastoma 3D spheres

Name: sara Azeem

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: E2

Verified Customer | Posted 01/08/2020

Glioblstoma patient derived cell line E2 was cultured in a 3D model for 21 days and the level of hypoxia in the spheres were measured following treatment with Pimonidazole.

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