Pirenzepine dihydrochloride

Catalog # Availability Size / Price Qty
1071/100
Cat.No. 1071 - Pirenzepine dihydrochloride | C19H21N5O2.2HCl | CAS No. 29868-97-1
1 Image
Description: Selective M1 antagonist

Chemical Name: 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride

Purity: ≥98%

Product Details
Citations (13)
Supplemental Products
Reviews

Biological Activity

M1 muscarinic receptor selective antagonist. Inverse agonist activity reported.

Technical Data

M.Wt:
424.33
Formula:
C19H21N5O2.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at RT
CAS No:
29868-97-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Pirenzepine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Pirenzepine dihydrochloride include:

13 Citations: Showing 1 - 10

  1. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
    Authors: Thomson Et al.
    Neuron  2017;95:550
  2. Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction.
    Authors: Nadal Et al.
    Front Cell Neurosci  2016;9:67
  3. STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
    Authors: Tian Et al.
    Scientific Reports  2016;6:36684
  4. Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
    Authors: Ahmed
    Physiological Reports  2016;4:e13069
  5. Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs.
    Authors: Pediani Et al.
    J.Biol.Chem.  2016;291:13132
  6. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
    Authors: Martin Et al.
    Proc Natl Acad Sci U S A  2015;9:457
  7. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  8. M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells.
    Authors: Pacini Et al.
    Cancer Biol Ther  2014;15:1489
  9. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
    Authors: Mans Et al.
    J Neurophysiol  2014;112:2388
  10. A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.
    Authors: Tozzi Et al.
    PLoS One  2012;7:e38312

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Reviews for Pirenzepine dihydrochloride

There are currently no reviews for this product. Be the first to review Pirenzepine dihydrochloride and earn rewards!

Have you used Pirenzepine dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.