Catalog Number: 1071
Chemical Name: 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
Biological Activity
M1 muscarinic receptor selective antagonist. Inverse agonist activity reported.
Technical Data
  • M.Wt:
    424.33
  • Formula:
    C19H21N5O2.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    29868-97-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle.
    Doods et al.
    Eur.J.Pharmacol., 1994;253:275
  2. Muscarinic receptor subtypes and smooth muscle function.
    Eglen et al.
    Pharmacol.Rev., 1996;48:531
  3. Inverse agonist activity of pirenzepine at M2 muscarinic acetylcholine receptors.
    Daeffler et al.
    Br.J.Pharmacol., 1999;126:1246
  4. Pirenzepine distinguishes between different subclasses of muscarinic receptors.
    Hammer et al.
    Nature, 1980;283:90
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pirenzepine dihydrochloride include:

10 Citations: Showing 1 - 10
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  1. Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction.
    Authors: Nadal Et al.
    Front Cell Neurosci 2016;9:67
  2. STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
    Authors: Tian Et al.
    Scientific Reports 2016;6:36684?
  3. Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
    Authors: Ahmed
    Physiological Reports 2016;4:?e13069
  4. Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs.
    Authors: Pediani Et al.
    J.Biol.Chem. 2016;291:13132
  5. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
    Authors: Martin Et al.
    Proc Natl Acad Sci U S A 2015;9:457
  6. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci 2015;9:192
  7. M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells.
    Authors: Pacini Et al.
    Cancer Biol Ther 2014;15:1489
  8. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
    Authors: Mans Et al.
    J Neurophysiol 2014;112:2388
  9. A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.
    Authors: Tozzi Et al.
    PLoS One 2012;7:e38312
  10. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
    Neuron 2010;68:948

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