Chemical Name: 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
Biological ActivityM1 muscarinic receptor selective antagonist. Inverse agonist activity reported.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle.
Doods et al.
Muscarinic receptor subtypes and smooth muscle function.
Eglen et al.
Inverse agonist activity of pirenzepine at M2 muscarinic acetylcholine receptors.
Daeffler et al.
Pirenzepine distinguishes between different subclasses of muscarinic receptors.
Hammer et al.
Citations for Pirenzepine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Pirenzepine dihydrochloride include:
13 Citations: Showing 1 - 10
Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
Authors: Thomson Et al.
Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction.
Authors: Nadal Et al.
Front Cell Neurosci 2016;9:67
STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
Authors: Tian Et al.
Scientific Reports 2016;6:36684
Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
Physiological Reports 2016;4:e13069
Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs.
Authors: Pediani Et al.
Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
Authors: Martin Et al.
Proc Natl Acad Sci U S A 2015;9:457
Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells.
Authors: Pacini Et al.
Cancer Biol Ther 2014;15:1489
An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
Authors: Mans Et al.
J Neurophysiol 2014;112:2388
A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.
Authors: Tozzi Et al.
PLoS One 2012;7:e38312
Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.
Authors: Hulme Et al.
J Neurosci 2012;32:6785
Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
Authors: Buchanan Et al.
The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals.
Authors: Garcia Et al.
J Neurosci 2010;30:16514
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