Piribedil dihydrochloride
Discontinued Product
Chemical Name: 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride
Purity: ≥99%
Biological Activity
Piribedil dihydrochloride is a direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
In vitro affinity of piribedil for DA D3 receptor subtypes, an autoradiographic study.
Cagnotto et al.
Eur.J.Pharmacol., 1996;313:63 -
Parkinson's disease: pathological mechanisms and actions of piribedil.
Jenne
J.Neurol., 1992;239:S2 -
A comparative study of the locomotor activity effects of apomor. and the 'atypical DA agonists' (piribedil and S36080).
Offermeier and van Rooyen
Life Sci., 1986;38:895
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for Piribedil dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Piribedil dihydrochloride include:
1 Citation: Showing 1 - 1
-
Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar DArgic D2 activity after REM sleep deprivation.
Authors: Rodrigues Et al.
Front Cell Neurosci 2014;8:383
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Piribedil dihydrochloride
There are currently no reviews for this product. Be the first to review Piribedil dihydrochloride and earn rewards!
Have you used Piribedil dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
