Catalog Number: 1031
Chemical Name: 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride
Biological Activity
A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic study.
    Cagnotto et al.
    Eur.J.Pharmacol., 1996;313:63
  3. Parkinson's disease: pathological mechanisms and actions of piribedil.
    J.Neurol., 1992;239:S2
  4. A comparative study of the locomotor activity effects of apomorphine and the 'atypical dopamine agonists' (piribedil and S36080).
    Offermeier and van Rooyen
    Life Sci., 1986;38:895

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