PK 11195

Tocris Bioscience | Catalog # 0670

Antagonist at peripheral benzodiazepine receptors
Tocris Bioscience
Discontinued Product
0670 has been discontinued. View all Translocator Protein Ligands products.

Key Product Details

Description

Antagonist at peripheral benzodiazepine receptors
View all Translocator Protein Ligands »

Product Description

PK 11195 has high affinity for the peripheral benzodiazepine receptor (PBR, TSPO) without binding to other known neurotransmitter receptors. Also inhibits the human constitutive androstane receptor (hCAR).

Product Specifications for PK 11195

Molecular Weight

352.86

Formula

C21H21ClN2O

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide

CAS Number

85532-75-8

PubChem ID

1345

InChI Key

RAVIZVQZGXBOQO-UHFFFAOYSA-N

SMILES

CCC(C)N(C)C(=O)C1=NC(C2=CC=CC=C2Cl)=C2C=CC=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.64 50
Ethanol 17.64 50

Preparing Stock Solutions for PK 11195

The following data is based on the product molecular weight 352.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.67 mL 28.34 mL 56.68 mL
2.5 mM 1.13 mL 5.67 mL 11.34 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
25 mM 0.11 mL 0.57 mL 1.13 mL

Calculators

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Product Documents for PK 11195

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PK 11195

For research use only

Customer Reviews for PK 11195 (1)

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  • A peripheral benzodiazepine receptor (PBR) agonist.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 05/02/2018
    It is a peripheral benzodiazepine receptor (PBR) agonist. It is effective in inhibiting LPS-induced pro-inflammatory cytokines such as IL-1beta and TNF-alpha in microglia culture.

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