Catalog Number: 0670
Chemical Name: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Biological Activity
Possesses high affinity for the peripheral benzodiazepine receptor (PBR, TSPO) without binding to other known neurotransmitter receptors. Also inhibits the human constitutive androstane receptor (hCAR).
Technical Data
  • M.Wt:
    352.86
  • Formula:
    C21H21ClN2O
  • Solubility:
    Soluble to 50 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    85532-75-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human androstane receptor.
    Li et al.
    Mol.Pharmacol., 2008;74:443
  2. Differentiation between two ligands for peripheral benzodiazpine binding sites [3H]-Ro 5-4864 and [3H]-PK11195, by thermodynamic studies.
    Le Fur et al.
    Life Sci., 1983;33:449
  3. Temporal changes in glial fibrillary acidic protein messenger RNA and [3H]PK11195 binding in relation to imidazoline-I2-receptor and α2-adrenoceptor binding in the hippocampus following transient global forebrain isch
    Conway et al.
    Neuroscience, 1998;82:805
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PK 11195 include:

2 Citations: Showing 1 - 2
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  1. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.
    Authors: Gut Et al.
    J Cell Mol Med 2013;9:97
  2. Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway.
    Authors: Sutter Et al.
    Nat Chem Biol 2003;89:564

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