PK-THPP

Catalog # Availability Size / Price Qty
5338/10
5338/50
Two-P Potassium Channels Blockers Small Molecule
1 Image
Description: Potent K2P9.1 (TASK-3) channel blocker

Chemical Name: 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone

Purity: ≥99%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.

Technical Data

M.Wt:
468.59
Formula:
C29H32N4O2
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in 1eq. HCl with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1332454-07-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for PK-THPP

The citations listed below are publications that use Tocris products. Selected citations for PK-THPP include:

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PH-THPP exhibits concentration dependent blocking activity
By Eleanor Baxter on 10/29/2018
Species: Human

A very potent K2p channel blocker which was used to figure out the blocking activity as concentration of the blocker molecule increased. PK-THPP is a great antagonist molecule which shows channel obstructing properties which is concentration dependent.


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