Catalog Number: 5338
Chemical Name: 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
Biological Activity
Potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.
Technical Data
  • M.Wt:
    468.59
  • Formula:
    C29H32N4O2
  • Solubility:
    Soluble to 50 mM in DMSO and to 20 mM in 1eq. HCl with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1332454-07-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats.
    Cotten
    Anesth.Analg., 2013;116:810
  2. Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3).
    Coburn et al.
    ChemMedChem, 2012;7:123

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