Chemical Name: 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
Biological ActivityPK-THPP is a potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats.
Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3).
Coburn et al.
Citation for PK-THPP
The citations listed below are publications that use Tocris products. Selected citations for PK-THPP include:
1 Citation: Showing 1 - 1
Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel.
Authors: Veldkamp Et al.
Nat Commun 2018;9:4357
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A very potent K2p channel blocker which was used to figure out the blocking activity as concentration of the blocker molecule increased. PK-THPP is a great antagonist molecule which shows channel obstructing properties which is concentration dependent.