PK-THPP

Tocris Bioscience | Catalog # 5338

Potent K2P9.1 (TASK-3) channel blocker
Tocris Bioscience

Key Product Details

Description

Potent K2P9.1 (TASK-3) channel blocker
View all Two-P Potassium Channels Blockers »

Product Description

PK-THPP is a potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.

Product Specifications for PK-THPP

Molecular Weight

468.59

Formula

C29H32N4O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone

CAS Number

1332454-07-5

PubChem ID

53464059

InChI Key

CJZGRIRZVHNUSM-UHFFFAOYSA-N

SMILES

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N(C3)CCC4=C3C(N5CCC(C(CCC)=O)CC5)=NC=N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 9.37 20 with gentle warming
DMSO 23.43 50

Preparing Stock Solutions for PK-THPP

The following data is based on the product molecular weight 468.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.27 mL 21.34 mL 42.68 mL
2.5 mM 0.85 mL 4.27 mL 8.54 mL
5 mM 0.43 mL 2.13 mL 4.27 mL
25 mM 0.09 mL 0.43 mL 0.85 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for PK-THPP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PK-THPP

For research use only

Customer Reviews for PK-THPP (1)

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  • PH-THPP exhibits concentration dependent blocking activity
    Name: Eleanor Baxter
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/29/2018
    A very potent K2p channel blocker which was used to figure out the blocking activity as concentration of the blocker molecule increased. PK-THPP is a great antagonist molecule which shows channel obstructing properties which is concentration dependent.
    PK-THPP 5338

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