PKA inhibitor fragment (6-22) amide

  ( 5 citations )    
Product Datasheet
Catalog Number:1904
Alternate Names:Protein kinase inhibitor-(6-22)-amide, PKI-(6-22)-amide
Chemical Name:
Product Details
Citations (5)
Reviews
Biological Activity
Potent inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.
Technical Data
  • M.Wt:
    1868.08
  • Formula:
    C80H130N28O24
  • Sequence:
    TYADFIASGRTGRRNAI

    (Modifications: Ile-17 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    121932-06-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PKA inhibitor fragment (6-22) amide include:

5 Citations: Showing 1 - 5
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  1. Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
    Authors: Cui Et al.
    Elife  2016;5:e13185
  2. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
    Authors: Pleil Et al.
    Nat Neurosci  2015;18:545
  3. PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
    Authors: Caiati Et al.
    J Neurosci  2013;33:2973
  4. Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.
    Authors: Tumati Et al.
    J Neurosci  2009;330:810
  5. Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons.
    Authors: Hopf Et al.
    FASEB J  2005;25:985

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