PKA inhibitor fragment (6-22) amide
Biological ActivityPKA inhibitor fragment (6-22) amide is a potent inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.
(Modifications: Ile-17 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein.
Glass et al.
Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10.
Glass et al.
Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses.
Otmakhova et al.
Citations for PKA inhibitor fragment (6-22) amide
The citations listed below are publications that use Tocris products. Selected citations for PKA inhibitor fragment (6-22) amide include:
7 Citations: Showing 1 - 7
Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C.
Authors: O'Neill & Sylantyev
Exp Biol Med (Maywood) 2018;243:1046
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome.
Authors: Costa Et al.
Front Mol Neurosci 2018;11:353
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Authors: Cui Et al.
NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
Authors: Pleil Et al.
Nat Neurosci 2015;18:545
PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
Authors: Caiati Et al.
J Neurosci 2013;33:2973
Sustained mor. treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.
Authors: Tumati Et al.
J Neurosci 2009;330:810
Atypical protein kinase C is a novel mediator of DA-enhanced firing in nucleus accumbens neurons.
Authors: Hopf Et al.
FASEB J 2005;25:985
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PKA inhibitor fragment (PKI) was used to compare effects of PKA and G-protein signalling on root mean square noise (RMS) produced by GABA-A receptors in electrophysiological recording. We found that after block of PKA with PKI GABA-A receptor antagonists SR 95531 and Picrotoxin generate stronger impact on RMS noise than after block of G-protein signalling with pertussis toxin.