PKA inhibitor fragment (6-22) amide (CAS 121932-06-7): R&D Systems
Catalog Number: 1904
Alternate Names: Protein kinase inhibitor-(6-22)-amide, PKI-(6-22)-amide
Biological Activity
Potent inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.
Technical Data
  • M.Wt:
    1868.08
  • Formula:
    C80H130N28O24
  • Sequence:
    TYADFIASGRTGRRNAI

    (Modifications: Ile-17 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    121932-06-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10.
    Glass et al.
    J.Biol.Chem., 1989;264:14579
  2. Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses.
    Otmakhova et al.
    J.Neurosci., 2000;20:4446
  3. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein.
    Glass et al.
    J.Biol.Chem., 1989;264:8802
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PKA inhibitor fragment (6-22) amide include:

3 Citations: Showing 1 - 3
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  1. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
    Authors: Pleil Et al.
    Nat Neurosci 2015;18:545
  2. Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.
    Authors: Tumati Et al.
    J Neurosci 2009;330:810
  3. Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons.
    Authors: Hopf Et al.
    FASEB J 2005;25:985

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