PKA inhibitor fragment (6-22) amide

Catalog # Availability Size / Price Qty
1904/1
PKA inhibitor fragment (6-22) amide
1 Image
Description: Potent protein kinase A inhibitor
Alternative Names: Protein kinase inhibitor-(6-22)-amide, PKI-(6-22)-amide
Product Details
Citations (7)
Reviews (1)

Biological Activity

Potent inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.

Technical Data

M.Wt:
1868.08
Formula:
C80H130N28O24
Sequence:
TYADFIASGRTGRRNAI

(Modifications: Ile-17 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
121932-06-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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PKI removes PKA control over RMS noise
By Anonymous on 07/21/2019
Species: Rat

PKA inhibitor fragment (PKI) was used to compare effects of PKA and G-protein signalling on root mean square noise (RMS) produced by GABA-A receptors in electrophysiological recording. We found that after block of PKA with PKI GABA-A receptor antagonists SR 95531 and Picrotoxin generate stronger impact on RMS noise than after block of G-protein signalling with pertussis toxin.

PMID: 30205722

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