PKA inhibitor fragment (6-22) amide

Tocris Bioscience | Catalog # 1904

Potent protein kinase A inhibitor
Tocris Bioscience
Discontinued Product
1904 has been discontinued. View all Protein Kinase A Inhibitors products.

Key Product Details

Description

Potent protein kinase A inhibitor

Alternative Names

Protein kinase inhibitor-(6-22)-amide,PKI-(6-22)-amide
View all Protein Kinase A Inhibitors »

Product Description

PKA inhibitor fragment (6-22) amide is a potent inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM); derived from the active portion of the heat-stable PKA inhibitor protein PKI.

Product Specifications for PKA inhibitor fragment (6-22) amide

Molecular Weight

1868.08

Formula

C80H130N28O24

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

121932-06-7

PubChem ID

16155227

InChI Key

VAKHFAFLRUNHLQ-PEBJKXEYSA-N

SMILES

[H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Product Documents for PKA inhibitor fragment (6-22) amide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PKA inhibitor fragment (6-22) amide

For research use only

Citations for PKA inhibitor fragment (6-22) amide

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  • PKI removes PKA control over RMS noise
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 07/21/2019
    PKA inhibitor fragment (PKI) was used to compare effects of PKA and G-protein signalling on root mean square noise (RMS) produced by GABA-A receptors in electrophysiological recording. We found that after block of PKA with PKI GABA-A receptor antagonists SR 95531 and Picrotoxin generate stronger impact on RMS noise than after block of G-protein signalling with pertussis toxin.
    PKA inhibitor fragment (6-22) amide 1904

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