PKI 14-22 amide, myristoylated

  ( 10 citations )    
Product Datasheet
Catalog Number:2546
Alternate Names:Protein kinase inhibitor-(14-22)-amide, myristoylated
Chemical Name:
Product Details
Citations (10)
Reviews
Biological Activity
Cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).
Technical Data
  • M.Wt:
    1209.5
  • Formula:
    C53H100N20O12
  • Sequence:
    GRTGRRNAI

    (Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    201422-03-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PKI 14-22 amide, myristoylated include:

10 Citations: Showing 1 - 10
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  1. The Orphan G Protein-Coupled Receptor Gpr175 (TPRA40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
    Authors: Singh Et al.
    J Biol Chem  2015;NULL
  2. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
    Authors: Muñoz-Llancao Et al.
    J Exp Med  2015;35:11315
  3. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
    Authors: Watson Et al.
    J Biol Chem  2015;212:1021
  4. Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase.
    Authors: Okumura Et al.
    PLoS One  2014;9:e100559
  5. GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
    Authors: Adelfinger Et al.
    Biochem Pharmacol  2014;91:369
  6. PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
    Authors: Caiati Et al.
    J Neurosci  2013;33:2973
  7. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  8. cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization.
    Authors: Maddugoda Et al.
    Cell Host Microbe  2011;10:464
  9. PKA-induced receptor activator of NF-κB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification.
    Authors: Tseng Et al.
    Autophagy  2010;285:29925
  10. Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.
    Authors: Liu Et al.
    Invest Ophthalmol Vis Sci  2008;49:772

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