PKI 14-22 amide, myristoylated

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PKI 14-22 amide, myristoylated
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Description: Cell-permeable protein kinase A inhibitor
Alternative Names: Protein kinase inhibitor-(14-22)-amide, myristoylated

Purity: ≥95%

Product Details
Citations (16)

Biological Activity

PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Technical Data


(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)

Soluble to 1 mg/ml in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for PKI 14-22 amide, myristoylated

The citations listed below are publications that use Tocris products. Selected citations for PKI 14-22 amide, myristoylated include:

16 Citations: Showing 1 - 10

  1. Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function.
    Authors: Jakobsen Et al.
    J Neurosci Res  2019;97:1018
  2. The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent.
    Authors: Al-Amily Et al.
    Pflugers Arch  2019;471:633
  3. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.
    Authors: Hamnett Et al.
    Nat Commun  2019;10:542
  4. Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm.
    Authors: Stival Et al.
    J Biol Chem  2018;293:9435
  5. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
    Authors: Hashimotodani Et al.
    Neuron  2017;95:928
  6. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels.
    Authors: Jantarajit Et al.
    Am J Physiol Cell Physiol  2017;313:C118
  7. The Orphan G Protein-Coupled Receptor Gpr175 (TPRA40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
    Authors: Singh Et al.
    J Biol Chem  2015;NULL
  8. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
    Authors: Muñoz-Llancao Et al.
    J Exp Med  2015;35:11315
  9. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
    Authors: Watson Et al.
    J Biol Chem  2015;212:1021
  10. Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase.
    Authors: Okumura Et al.
    PLoS One  2014;9:e100559


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