PKI 14-22 amide, myristoylated
Biological ActivityPKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).
(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein.
Glass et al.
Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1.
Zheng et al.
Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A.
Farrow et al.
Citations for PKI 14-22 amide, myristoylated
The citations listed below are publications that use Tocris products. Selected citations for PKI 14-22 amide, myristoylated include:
16 Citations: Showing 1 - 10
Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function.
Authors: Jakobsen Et al.
J Neurosci Res 2019;97:1018
The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent.
Authors: Al-Amily Et al.
Pflugers Arch 2019;471:633
Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.
Authors: Hamnett Et al.
Nat Commun 2019;10:542
Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm.
Authors: Stival Et al.
J Biol Chem 2018;293:9435
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Authors: Hashimotodani Et al.
CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels.
Authors: Jantarajit Et al.
Am J Physiol Cell Physiol 2017;313:C118
The Orphan G Protein-Coupled Receptor Gpr175 (TPRA40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
Authors: Singh Et al.
J Biol Chem 2015;NULL
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
Authors: Muñoz-Llancao Et al.
J Exp Med 2015;35:11315
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
Authors: Watson Et al.
J Biol Chem 2015;212:1021
Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase.
Authors: Okumura Et al.
PLoS One 2014;9:e100559
GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
Authors: Adelfinger Et al.
Biochem Pharmacol 2014;91:369
PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
Authors: Caiati Et al.
J Neurosci 2013;33:2973
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
Authors: Meitzen Et al.
J Neurochem 2011;116:984
cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization.
Authors: Maddugoda Et al.
Cell Host Microbe 2011;10:464
PKA-induced receptor activator of NF-κB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification.
Authors: Tseng Et al.
Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.
Authors: Liu Et al.
Invest Ophthalmol Vis Sci 2008;49:772
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