Catalog Number: 2546
Alternate Names: Protein kinase inhibitor-(14-22)-amide, myristoylated
Biological Activity
Cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 30% acetonitrile / water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein.
    Glass et al.
    J.Biol.Chem., 1989;264:8802
  2. Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1.
    Zheng et al.
    J.Biol.Chem., 2000;275:31747
  3. Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A.
    Farrow et al.
    Surgery, 2003;134:197

The citations listed below are publications that use Tocris products. Selected citations for PKI 14-22 amide, myristoylated include:

Showing Results 1 - 9 of 9

  1. The Orphan G Protein-Coupled Receptor Gpr175 (TPRA40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
    Authors: Singh Et al.
    J Biol Chem
  2. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
    Authors: Muñoz-Llancao Et al.
    J Exp Med
  3. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
    Authors: Watson Et al.
    J Biol Chem
  4. Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase.
    Authors: Okumura Et al.
    PLoS One
  5. GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
    Authors: Adelfinger Et al.
    Biochem Pharmacol
  6. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem
  7. cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization.
    Authors: Maddugoda Et al.
    Cell Host Microbe
  8. PKA-induced receptor activator of NF-κB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification.
    Authors: Tseng Et al.
  9. Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.
    Authors: Liu Et al.
    Invest Ophthalmol Vis Sci
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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