PKI (5-24)

Name: PKI (5-24)
Brand: Tocris Bioscience
SKU: 6221
Price: 210 USD
Availability: InStock

Tocris Bioscience | Catalog # 6221

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Citations (7)

Product Documents

High affinity PKA inhibitor

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

High affinity PKA inhibitor

View all Protein Kinase A Inhibitors »

Product Description

PKI (5-24) is a high affinity PKA inhibitor (K_i = 2.3 nM).

Product Specifications for PKI (5-24)

Molecular Weight

2222.40

Formula

C₉₄H₁₄₈N₃₂O₃₁

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

99534-03-9

PubChem ID

102397230

InChI Key

AXOXZJJMUVSZQY-LGGJAOENSA-N

SMILES

[H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Narayana Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry 1997 PMID: 9109651
Cheng A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J.Biol.Chem. 1986 PMID: 3511044

Product Documents for PKI (5-24)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for PKI (5-24)

For research use only

Related Research Areas

Apoptosis Intracellular Kinases

Intracellular Kinases

Citations for PKI (5-24)

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